| Gene Information | |
|---|---|
| Gene Name | SCUBE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 988 |
| Protein Names | Signal peptide, CUB and EGF-like domain-containing protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000159307 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IWY4 |
| Gene Card | SCUBE1 |
| Uniprot ID | Q8IWY4 |
| Pfam | PF12662; PF00431; PF12947; PF07645; PF07699 |
| In ASD | no |
| Allosteric Prediction | no (-0.801695674) |
| Ortholog in Animals | Alpaca_ SCUBE1 ( ortholog_one2one ) Dog_ SCUBE1 ( ortholog_one2one ) GuineaPig_ SCUBE1 ( ortholog_one2one ) Macaque_ SCUBE1 ( ortholog_one2one ) Mouse_ Scube1 ( ortholog_one2one ) Pig_ SCUBE1 ( ortholog_one2one ) Rat_ Scube1 ( ortholog_one2one ) |
| Ohnologs | SCUBE3, SCUBE2 |
| Paralogs | SCUBE3, SCUBE2 |
| Tissue | esophagus.muscularis.mucosa, ovary, tibial.nerve |
| Tissue Specificity | Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques. {ECO:0000269|PubMed:12270931, ECO:0000269|PubMed:16753137}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs129415 rs138993 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12270931, ECO:0000269|PubMed:16753137}. Cell membrane {ECO:0000269|PubMed:16753137}; Peripheral membrane protein {ECO:0000269|PubMed:16753137}. |
| Mouse PG classification | NA |
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