| Gene Information | |
|---|---|
| Gene Name | SLC38A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 547 |
| Protein Names | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) |
| Target Name | sodium-coupled neutral amino acid transporters |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000139209 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q969I6 |
| Gene Card | SLC38A4 |
| Uniprot ID | Q969I6 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | no (-0.43878359) |
| Ortholog in Animals | Alpaca_ SLC38A4 ( ortholog_one2one ) Dog_ SLC38A4 ( ortholog_one2one ) GuineaPig_ SLC38A4 ( ortholog_one2one ) Macaque_ SLC38A4 ( ortholog_one2one ) Mouse_ Slc38a4 ( ortholog_one2one ) Pig_ SLC38A4 ( ortholog_one2one ) Rat_ Slc38a4 ( ortholog_one2one ) Rabbit_ SLC38A4 ( ortholog_one2one ) |
| Ohnologs | SLC38A5, SLC38A3 |
| Paralogs | SLC38A3, SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A8, SLC38A2, SLC36A2, SLC38A11, SLC38A6, SLC32A1, SLC38A1, SLC38A5 |
| Tissue | liver |
| Tissue Specificity | Expressed almost exclusively in embryonic and adult liver, and at lower levels in the kidney (PubMed:11342143, PubMed:11414754). Expressed at lower levels in adult muscle and pancreas (PubMed:11414754). Detected in fetal blood vessels (PubMed:16148032). Expressed in syncytiotrophoblas of placenta during first trimester and at term (PubMed:19015196, PubMed:16148032). Highly expressed in first trimester placenta compared to term placenta (PubMed:19015196). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032, ECO:0000269|PubMed:19015196}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2429467 rs11183610 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754}. Cell projection, microvillus membrane {ECO:0000269|PubMed:19015196}; Multi-pass membrane protein. Note=Microvillus membrane localization in placenta. {ECO:0000269|PubMed:19015196}. |
| Mouse PG classification | NA |
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