| Gene Information | |
|---|---|
| Gene Name | DNASE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000105612 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00115 |
| Gene Card | DNASE2 |
| Uniprot ID | O00115 |
| Pfam | PF03265 |
| In ASD | no |
| Allosteric Prediction | no (-0.603713881) |
| Ortholog in Animals | Alpaca_ DNASE2 ( ortholog_one2one ) Dog_ DNASE2 ( ortholog_one2one ) GuineaPig_ DNASE2 ( ortholog_one2one ) Macaque_ DNASE2 ( ortholog_one2one ) Mouse_ Dnase2a ( ortholog_one2one ) Pig_ DNASE2 ( ortholog_one2one ) Rat_ Dnase2 ( ortholog_one2one ) Rabbit_ DNASE2 ( ortholog_one2one ) |
| Ohnologs | DNASE2B |
| Paralogs | DNASE2B |
| Tissue | NA |
| Tissue Specificity | Expressed in monocytes/macrophages (at protein level). {ECO:0000269|PubMed:29259162}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs36075196 rs201030953 rs16978744 rs1061192 |
| Subcellular location [CC] | Lysosome. |
| Mouse PG classification | NA |
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