Gene Information
Gene NameSCNN1B
OrganismHomo sapiens (Human)
Gene Length640
Protein NamesAmiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Target Nameamiloride-sensitive sodium channel subunit beta
Target TypeNA
Gene Age645 ( ENSG00000168447 )
Evolutionary StageEumetazoa
AlphaFoldDBP51168
Gene CardSCNN1B
Uniprot IDP51168
PfamPF00858
In ASDno
Allosteric Predictionyes (0.557080862)
Ortholog in AnimalsAlpaca_ SCNN1B ( ortholog_one2one )
Dog_ SCNN1B ( ortholog_one2one )
GuineaPig_ Scnn1b ( ortholog_one2one )
Macaque_ SCNN1B ( ortholog_one2one )
Mouse_ Scnn1b ( ortholog_one2one )
Pig_ SCNN1B ( ortholog_one2one )
Rat_ Scnn1b ( ortholog_one2one )
Rabbit_ SCNN1B ( ortholog_one2one )
OhnologsASIC2
ParalogsASIC1, ASIC5, SCNN1G, ASIC4, SCNN1A, SCNN1D, ASIC2, ASIC3
TissueNA
Tissue SpecificityDetected in placenta, lung and kidney (PubMed:7762608). Expressed in kidney (at protein level) (PubMed:22207244). {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:7762608}.
Pharmacological Animal Models0.675000(Chimpanzee);0.676923(Mouse);0.980067(Rat);0.270699(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6BQN  (EM  3.90A  )  6WTH  (EM  3.06A  ) 
DBSNP rs137852706  rs35731153  rs137852709  rs137852712  rs72654338  rs777888930  rs61759921  rs137852711  rs201330438  rs1799980  rs137852710  rs149868979  rs61759926  rs1799979  rs140945152  rs387906402  rs137852708  rs137852705  rs137852707  rs372132399 
Subcellular location [CC]Apical cell membrane {ECO:0000305|PubMed:7490094};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}. Note=Apical membrane of epithelial cells. {ECO:0000305|PubMed:7490094}.
Mouse PG classificationHPG
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