| Gene Information | |
|---|---|
| Gene Name | GHRL |
| Organism | Homo sapiens (Human) |
| Gene Length | 117 |
| Protein Names | Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin] |
| Target Name | ghrelin |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000157017 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UBU3 |
| Gene Card | GHRL |
| Uniprot ID | Q9UBU3 |
| Pfam | PF04643; PF04644 |
| In ASD | no |
| Allosteric Prediction | yes (0.28345545) |
| Ortholog in Animals | Alpaca_ GHRL ( ortholog_one2one ) Dog_ GHRL ( ortholog_one2one ) GuineaPig_ GHRL ( ortholog_one2one ) Macaque_ GHRL ( ortholog_one2one ) Mouse_ Ghrl ( ortholog_one2one ) Pig_ GHRL ( ortholog_one2one ) Rat_ Ghrl ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | stomach |
| Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy. {ECO:0000269|PubMed:12414809}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6H3E (NMR - ) 7F9Y (EM 2.90A ) 7NA7 (EM 2.70A ) 7W2Z (EM 2.80A ) |
| DBSNP | rs696217 rs4684677 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | LPG |
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