| Gene Information | |
|---|---|
| Gene Name | SCN9A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1988 |
| Protein Names | Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) |
| Target Name | voltage-gated sodium channel alpha subunit |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000169432 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15858 |
| Gene Card | SCN9A |
| Uniprot ID | Q15858 |
| Pfam | PF00520; PF06512; PF11933 |
| In ASD | no |
| Allosteric Prediction | yes (1.179304428) |
| Ortholog in Animals | Alpaca_ SCN9A ( ortholog_one2one ) Dog_ SCN9A ( ortholog_one2one ) GuineaPig_ SCN9A ( ortholog_one2one ) Macaque_ SCN9A ( ortholog_one2one ) Mouse_ Scn9a ( ortholog_one2one ) Pig_ SCN9A ( ortholog_one2one ) Rat_ Scn9a ( ortholog_one2one ) Rabbit_ SCN9A ( ortholog_one2one ) |
| Ohnologs | SCN4A, SCN11A, SCN5A, SCN10A, SCN8A |
| Paralogs | SCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A |
| Tissue | NA |
| Tissue Specificity | Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Also expressed in vagus nerves within the head and neck region (PubMed:31647222). Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. {ECO:0000269|PubMed:15178348, ECO:0000269|PubMed:15302875, ECO:0000269|PubMed:31647222, ECO:0000269|PubMed:7720699, ECO:0000269|PubMed:9169448}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5EK0 (X-ray 3.53A ) 6J8G (EM 3.20A ) 6J8H (EM 3.20A ) 6J8I (EM 3.20A ) 6J8J (EM 3.20A ) 6N4Q (EM 3.60A ) 6N4R (EM 4.20A ) 6NT3 (EM 3.40A ) 6NT4 (EM 3.50A ) 6VXO (EM 3.50A ) 6W6O (EM 3.20A ) 7K48 (EM 3.60A ) 7W9K (EM 2.20A ) 7W9L (EM 3.50A ) 7W9M (EM 3.00A ) 7W9P (EM 2.90A ) 7W9T (EM 3.00A ) 7XVE (EM 2.70A ) 7XVF (EM 2.80A ) |
| DBSNP | rs267607030 rs121908920 rs121908921 rs80356469 rs71428908 rs80356470 rs80356471 rs58022607 rs187453572 rs121908918 rs121908919 rs199588089 rs201709980 rs182650126 rs80356474 rs80356476 rs80356475 rs1024152367 rs12478318 rs12478318 rs121908910 rs200160858 rs6746030 rs180922748 rs121908911 rs121908912 rs121908913 rs80356478 rs121908914 rs1553474394 rs121908915 rs1131691776 rs879253994 rs3750904 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15385606, ECO:0000269|PubMed:17167479, ECO:0000269|PubMed:19369487, ECO:0000269|PubMed:24311784, ECO:0000269|PubMed:25240195, ECO:0000269|PubMed:26680203, ECO:0000269|PubMed:7720699}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08562}. Note=In neurite terminals. {ECO:0000250|UniProtKB:O08562}. |
| Mouse PG classification | NA |
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