| Gene Information | |
|---|---|
| Gene Name | GPR6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | G-protein coupled receptor 6 (Sphingosine 1-phosphate receptor GPR6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146360 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P46095 |
| Gene Card | GPR6 |
| Uniprot ID | P46095 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.659005335) |
| Ortholog in Animals | Alpaca_ GPR6 ( ortholog_one2one ) Dog_ GPR6 ( ortholog_one2one ) Macaque_ GPR6 ( ortholog_one2one ) Mouse_ Gpr6 ( ortholog_one2one ) Rat_ Gpr6 ( ortholog_one2one ) Rabbit_ GPR6 ( ortholog_one2one ) |
| Ohnologs | MC3R, GPR12, GPR3 |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, MC5R, MC1R, MC2R, MC3R, MC4R, GPR3, GPR12, GPR119, CNR1, CNR2 |
| Tissue | caudate.nucleus, diencephalon, putamen, nucleus.accumbens |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:19059244}; Multi-pass membrane protein {ECO:0000305|PubMed:19059244}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor. |
| Mouse PG classification | NA |
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