| Gene Information | |
|---|---|
| Gene Name | SCN4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 228 |
| Protein Names | Sodium channel subunit beta-4 |
| Target Name | sodium channel protein |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000177098 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IWT1 |
| Gene Card | SCN4B |
| Uniprot ID | Q8IWT1 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.722733663) |
| Ortholog in Animals | Alpaca_ SCN4B ( ortholog_one2one ) GuineaPig_ SCN4B ( ortholog_one2one ) Macaque_ SCN4B ( ortholog_one2one ) Mouse_ Scn4b ( ortholog_one2one ) Rat_ Scn4b ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCN2B, MPZL1, JAML, MPZ, MPZL3, MPZL2 |
| Tissue | NA |
| Tissue Specificity | Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium. {ECO:0000269|PubMed:12930796, ECO:0000269|PubMed:21051419}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4MZ2 (X-ray 1.72A ) 4MZ3 (X-ray 1.74A ) 5XAW (X-ray 2.10A ) 6VSV (X-ray 1.62A ) 7DTD (EM 3.30A ) |
| DBSNP | rs587777559 rs587777560 rs121434386 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}. |
| Mouse PG classification | NA |
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