| Gene Information | |
|---|---|
| Gene Name | LIMD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 676 |
| Protein Names | LIM domain-containing protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000144791 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UGP4 |
| Gene Card | LIMD1 |
| Uniprot ID | Q9UGP4 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | no (-0.542138613) |
| Ortholog in Animals | Alpaca_ LIMD1 ( ortholog_one2one ) Dog_ LIMD1 ( ortholog_one2one ) GuineaPig_ LIMD1 ( ortholog_one2one ) Macaque_ LIMD1 ( ortholog_one2one ) Mouse_ Limd1 ( ortholog_one2one ) Pig_ LIMD1 ( ortholog_one2one ) Rat_ Limd1 ( ortholog_one2one ) Rabbit_ LIMD1 ( ortholog_one2one ) |
| Ohnologs | TRIP6, AJUBA, LPP, ZYX |
| Paralogs | AJUBA, WTIP |
| Tissue | NA |
| Tissue Specificity | Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. {ECO:0000269|PubMed:10647888, ECO:0000269|PubMed:18712738}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2578662 rs3733113 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis. |
| Mouse PG classification | NA |
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