| Gene Information | |
|---|---|
| Gene Name | PINK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 581 |
| Protein Names | Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158828 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BXM7 |
| Gene Card | PINK1 |
| Uniprot ID | Q9BXM7 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.303007338) |
| Ortholog in Animals | Alpaca_ PINK1 ( ortholog_one2one ) Dog_ PINK1 ( ortholog_one2one ) GuineaPig_ PINK1 ( ortholog_one2one ) Macaque_ PINK1 ( ortholog_one2one ) Mouse_ Pink1 ( ortholog_one2one ) Pig_ PINK1 ( ortholog_one2one ) Rat_ Pink1 ( ortholog_one2one ) Rabbit_ PINK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PEAK3, PEAK1, PRAG1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. {ECO:0000269|PubMed:11494141}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005882(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs763142730 rs1385309950 rs1553145550 rs575668171 rs1553145560 rs148871409 rs1274588239 rs775809722 rs45604240 rs138050841 rs56297806 rs768091663 rs1553145929 rs143204084 rs138302371 rs35802484 rs34677717 rs371854396 rs74315360 rs1303935100 rs1557562082 rs573931674 rs370906995 rs1553146419 rs372280083 rs28940284 rs548506734 rs74315358 rs772510148 rs779060308 rs7349186 rs74315355 rs74315359 rs200949139 rs139226733 rs768019187 rs55831733 rs3738136 rs35813094 rs28940285 rs1195888869 rs34203620 rs45515602 rs1553146806 rs1035071310 rs119451946 rs556540177 rs1553146818 rs45478900 rs1553146822 rs554114655 rs74315361 rs1553146877 rs747400197 rs764328076 rs115477764 rs34416410 rs1553146903 rs34208370 rs61744200 rs1043424 rs531477772 rs771032673 rs1553147052 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:16672980, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:31536960}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22354088}. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282). {ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105}. |
| Mouse PG classification | LPG |
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