| Gene Information | |
|---|---|
| Gene Name | LGALS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 250 |
| Protein Names | Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) |
| Target Name | galectin-3 |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000131981 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17931 |
| Gene Card | LGALS3 |
| Uniprot ID | P17931 |
| Pfam | PF00337 |
| In ASD | yes |
| Allosteric Prediction | yes (0.308433646) |
| Ortholog in Animals | Alpaca_ LGALS3 ( ortholog_one2one ) Dog_ LGALS3 ( ortholog_one2one ) GuineaPig_ LGALS3 ( ortholog_one2one ) Macaque_ LGALS3 ( ortholog_one2one ) Mouse_ Lgals3 ( ortholog_one2one ) Pig_ LGALS3 ( ortholog_one2one ) Rat_ Lgals3 ( ortholog_one2one ) Rabbit_ LGALS3 ( ortholog_one2one ) |
| Ohnologs | LGALS7B, LGALS7 |
| Paralogs | LGALSL, GRIFIN, LGALS7, LGALS7B, LGALS1, LGALS4, LGALS12, LGALS8, LGALS2, LGALS13, LGALS14, LGALS16, LGALS9B, LGALS9, LGALS9C, CLC |
| Tissue | NA |
| Tissue Specificity | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. {ECO:0000269|PubMed:19497882}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1A3K (X-ray 2.10A ) 1KJL (X-ray 1.40A ) 1KJR (X-ray 1.55A ) 2NMN (X-ray 2.45A ) 2NMO (X-ray 1.35A ) 2NN8 (X-ray 1.35A ) 2XG3 (X-ray 1.20A ) 3AYA (X-ray 2.00A ) 3AYC (X-ray 1.80A ) 3AYD (X-ray 1.90A ) 3AYE (X-ray 2.00A ) 3T1L (X-ray 1.60A ) 3T1M (X-ray 1.55A ) 3ZSJ (X-ray 0.86A ) 3ZSK (X-ray 0.90A ) 3ZSL (X-ray 1.08A ) 3ZSM (X-ray 1.25A ) 4BLI (X-ray 1.08A ) 4BLJ (X-ray 1.20A ) 4BM8 (X-ray 0.96A ) 4JC1 (X-ray 1.50A ) 4JCK (X-ray 1.15A ) 4LBJ (X-ray 1.80A ) 4LBK (X-ray 1.60A ) 4LBL (X-ray 1.58A ) 4LBM (X-ray 1.55A ) 4LBN (X-ray 1.70A ) 4LBO (X-ray 1.65A ) 4R9A (X-ray 1.20A ) 4R9B (X-ray 1.20A ) 4R9C (X-ray 1.19A ) 4R9D (X-ray 1.24A ) 4RL7 (X-ray 2.00A ) 4XBN (X-ray 2.21A ) 5E88 (X-ray 1.60A ) 5E89 (X-ray 1.50A ) 5E8A (X-ray 1.50A ) 5EXO (X-ray 1.50A ) 5H9P (X-ray 2.04A ) 5H9R (X-ray 1.58A ) 5IUQ (X-ray 1.12A ) 5NF7 (X-ray 1.59A ) 5NF9 (X-ray 1.87A ) 5NFA (X-ray 1.59A ) 5NFB (X-ray 1.59A ) 5NFC (X-ray 1.59A ) 5OAX (X-ray 1.20A ) 5ODY (X-ray 1.15A ) 6B8K (X-ray 1.28A ) 6EOG (X-ray 1.20A ) 6EOL (X-ray 1.50A ) 6EXY (Other 1.10A ) 6EYM (Other 1.70A ) 6F2Q (Other 1.03A ) 6F6Y (X-ray 1.41A ) 6FK2 (X-ray 1.01A ) 6FOF (X-ray 2.20A ) 6G0V (X-ray 1.09A ) 6H64 (X-ray 1.80A ) 6I74 (X-ray 0.96A ) 6I75 (X-ray 1.17A ) 6I76 (X-ray 1.20A ) 6I77 (X-ray 1.22A ) 6I78 (X-ray 1.15A ) 6KXA (X-ray 1.23A ) 6KXB (X-ray 1.50A ) 6Q0Q (X-ray 1.99A ) 6Q17 (X-ray 1.98A ) 6QGE (X-ray 1.16A ) 6QGF (X-ray 1.34A ) 6QLN (X-ray 1.00A ) 6QLO (X-ray 1.18A ) 6QLP (X-ray 1.08A ) 6QLQ (X-ray 1.08A ) 6QLR (X-ray 0.97A ) 6QLS (X-ray 1.05A ) 6QLT (X-ray 1.15A ) 6QLU (X-ray 1.10A ) 6RHL (X-ray 1.30A ) 6RHM (X-ray 1.60A ) 6RZF (X-ray 1.02A ) 6RZG (X-ray 1.01A ) 6RZH (X-ray 0.95A ) 6RZI (X-ray 1.09A ) 6RZJ (X-ray 1.10A ) 6RZK (X-ray 1.05A ) 6RZL (X-ray 1.04A ) 6RZM (X-ray 1.34A ) 6TF6 (X-ray 1.50A ) 6TF7 (X-ray 1.40A ) 6Y4C (X-ray 1.70A ) 6Y78 (X-ray 1.70A ) 6ZVF (X-ray 1.90A ) 7BE3 (X-ray 1.25A ) 7CXA (X-ray 1.97A ) 7DF5 (X-ray 1.08A ) 7RDO (X-ray 1.99A ) 7RDP (X-ray 1.96A ) 7RGX (X-ray 1.58A ) 7RGY (X-ray 1.34A ) 7RGZ (X-ray 1.49A ) 7RH0 (X-ray 1.49A ) 7RH1 (X-ray 1.44A ) 7RH3 (X-ray 1.05A ) 7RH4 (X-ray 1.20A ) |
| DBSNP | rs4644 rs4652 rs10148371 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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