Gene Information
Gene NameSCN11A
OrganismHomo sapiens (Human)
Gene Length1791
Protein NamesSodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)
Target Namesodium channel protein
Target TypeNA
Gene Age382 ( ENSG00000168356 )
Evolutionary StageMammalia
AlphaFoldDBQ9UI33
Gene CardSCN11A
Uniprot IDQ9UI33
PfamPF00520; PF06512
In ASDno
Allosteric Predictionyes (0.857923074)
Ortholog in AnimalsAlpaca_ SCN11A ( ortholog_one2one )
Dog_ SCN11A ( ortholog_one2one )
GuineaPig_ SCN11A ( ortholog_one2one )
Macaque_ SCN11A ( ortholog_one2one )
Mouse_ Scn11a ( ortholog_one2one )
Pig_ SCN11A ( ortholog_one2one )
Rat_ Scn11a ( ortholog_one2one )
Rabbit_ SCN11A ( ortholog_one2one )
OhnologsSCN8A, SCN2A, SCN7A, SCN1A, SCN3A, SCN9A
ParalogsCACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
TissueNA
Tissue SpecificityExpressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. {ECO:0000269|PubMed:10623608, ECO:0000269|PubMed:15302875}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1230622899  rs138607170  rs751477540  rs606231280  rs150269814  rs13059805  rs141228634  rs145734191  rs4302324  rs483352921  rs483352920  rs1373209779  rs33985936  rs141686175  rs12638601  rs72869687  rs201107889 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:D0E0C2};
Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
Mouse PG classificationLPG
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