| Gene Information | |
|---|---|
| Gene Name | REN |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Renin (EC 3.4.23.15) (Angiotensinogenase) |
| Target Name | angiotensinogenase renin |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000143839 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P00797 |
| Gene Card | REN |
| Uniprot ID | P00797 |
| Pfam | PF07966; PF00026 |
| In ASD | no |
| Allosteric Prediction | yes (0.750525509) |
| Ortholog in Animals | Alpaca_ REN ( ortholog_one2one ) Dog_ REN ( ortholog_one2one ) GuineaPig_ REN ( ortholog_one2one ) Macaque_ REN ( ortholog_one2one ) Mouse_ Ren1 ( ortholog_one2one ) Pig_ REN ( ortholog_one2one ) Rat_ Ren ( ortholog_one2one ) Rabbit_ REN ( ortholog_one2one ) |
| Ohnologs | PGC, CTSD |
| Paralogs | PGC, BACE2, CTSE, BACE1, NAPSA, CTSD, PGA5, PGA4, PGA3 |
| Tissue | kidney, placenta, endometrium, ovary, cortex.of.kidney |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BBS (X-ray 2.80A ) 1BIL (X-ray 2.40A ) 1BIM (X-ray 2.80A ) 1HRN (X-ray 1.80A ) 1RNE (X-ray 2.40A ) 2BKS (X-ray 2.20A ) 2BKT (X-ray 2.30A ) 2FS4 (X-ray 2.20A ) 2G1N (X-ray 2.90A ) 2G1O (X-ray 2.70A ) 2G1R (X-ray 2.42A ) 2G1S (X-ray 2.50A ) 2G1Y (X-ray 2.50A ) 2G20 (X-ray 2.40A ) 2G21 (X-ray 2.20A ) 2G22 (X-ray 2.50A ) 2G24 (X-ray 1.90A ) 2G26 (X-ray 2.10A ) 2G27 (X-ray 2.90A ) 2I4Q (X-ray 2.30A ) 2IKO (X-ray 1.90A ) 2IKU (X-ray 2.60A ) 2IL2 (X-ray 2.24A ) 2REN (X-ray 2.50A ) 2V0Z (X-ray 2.20A ) 2V10 (X-ray 3.10A ) 2V11 (X-ray 3.10A ) 2V12 (X-ray 3.20A ) 2V13 (X-ray 2.80A ) 2V16 (X-ray 2.80A ) 2X0B (X-ray 4.33A ) 3D91 (X-ray 2.20A ) 3G6Z (X-ray 2.00A ) 3G70 (X-ray 2.00A ) 3G72 (X-ray 1.90A ) 3GW5 (X-ray 2.00A ) 3K1W (X-ray 1.50A ) 3KM4 (X-ray 1.90A ) 3O9L (X-ray 2.40A ) 3OAD (X-ray 2.17A ) 3OAG (X-ray 2.30A ) 3OOT (X-ray 2.55A ) 3OQF (X-ray 2.78A ) 3OQK (X-ray 2.90A ) 3OWN (X-ray 2.00A ) 3Q3T (X-ray 2.60A ) 3Q4B (X-ray 2.19A ) 3Q5H (X-ray 2.16A ) 3SFC (X-ray 2.10A ) 3VCM (X-ray 2.93A ) 3VSW (X-ray 3.00A ) 3VSX (X-ray 2.80A ) 3VUC (X-ray 2.60A ) 3VYD (X-ray 2.81A ) 3VYE (X-ray 2.70A ) 3VYF (X-ray 2.80A ) 4AMT (X-ray 2.60A ) 4GJ5 (X-ray 2.40A ) 4GJ6 (X-ray 2.58A ) 4GJ7 (X-ray 2.80A ) 4GJ8 (X-ray 2.50A ) 4GJ9 (X-ray 2.60A ) 4GJA (X-ray 2.60A ) 4GJB (X-ray 2.75A ) 4GJC (X-ray 2.40A ) 4GJD (X-ray 2.65A ) 4PYV (X-ray 2.65A ) 4Q1N (X-ray 2.09A ) 4RYC (X-ray 2.45A ) 4RYG (X-ray 2.65A ) 4RZ1 (X-ray 2.60A ) 4S1G (X-ray 2.10A ) 4XX3 (X-ray 2.40A ) 4XX4 (X-ray 2.40A ) 5KOQ (X-ray 2.70A ) 5KOS (X-ray 2.41A ) 5KOT (X-ray 2.10A ) 5SXN (X-ray 2.10A ) 5SY2 (X-ray 2.25A ) 5SY3 (X-ray 2.30A ) 5SZ9 (X-ray 2.85A ) 5T4S (X-ray 2.64A ) 5TMG (X-ray 2.20A ) 5TMK (X-ray 2.65A ) 5V8V (X-ray 2.60A ) 5VPM (X-ray 2.90A ) 5VRP (X-ray 3.22A ) 6I3F (X-ray 2.55A ) 7XGK (X-ray 2.40A ) 7XGO (X-ray 2.10A ) 7XGP (X-ray 2.65A ) |
| DBSNP | rs121917743 rs11571098 rs868694193 rs11571083 rs11571117 rs121917742 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12045255}. Membrane {ECO:0000269|PubMed:12045255}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000269|PubMed:12045255}. |
| Mouse PG classification | HPG |
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