Gene Information
Gene NameSCH
OrganismHomo sapiens (Human)
Gene Length595
Protein NamesMerlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP35240
Gene CardNF2
Uniprot IDP35240
PfamPF00769; PF20492; PF09380; PF00373; PF09379
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.021429(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1H4R  (X-ray  1.80A  )  3U8Z  (X-ray  2.64A  )  4ZRI  (X-ray  2.70A  )  4ZRJ  (X-ray  2.30A  )  6CDS  (X-ray  2.62A  )  7LWH  (X-ray  1.61A  ) 
DBSNP rs121434261  rs1555994816  rs1601618646  rs771675702  rs764441073  rs74315492  rs766974263  rs765540111  rs74315503  rs74315493  rs74315494 
Subcellular location [CC][Isoform 1]: Cell projection, filopodium membrane;
Peripheral membrane protein;
Cytoplasmic side. Cell projection, ruffle membrane;
Peripheral membrane protein;
Cytoplasmic side. Nucleus. Note=In a fibroblastic cell line, isoform 1 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia. Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions.;
[Isoform 7]: Cytoplasm, perinuclear region. Cytoplasmic granule. Note=Observed in cytoplasmic granules concentrated in a perinuclear location. Isoform 7 is absent from ruffling membranes and filopodia.;
[Isoform 9]: Cytoplasm, perinuclear region. Cytoplasmic granule. Note=Observed in cytoplasmic granules concentrated in a perinuclear location. Isoform 9 is absent from ruffling membranes and filopodia.;
[Isoform 10]: Nucleus. Cell projection, filopodium membrane;
Peripheral membrane protein;
Cytoplasmic side. Cell projection, ruffle membrane;
Peripheral membrane protein;
Cytoplasmic side. Cytoplasm, perinuclear region. Cytoplasmic granule. Cytoplasm, cytoskeleton. Note=In a fibroblastic cell line, isoform 10 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia.
Mouse PG classificationNA
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