| Gene Information | |
|---|---|
| Gene Name | SCGN |
| Organism | Homo sapiens (Human) |
| Gene Length | 276 |
| Protein Names | Secretagogin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000079689 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O76038 |
| Gene Card | SCGN |
| Uniprot ID | O76038 |
| Pfam | PF13202; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.817071278) |
| Ortholog in Animals | Alpaca_ SCGN ( ortholog_one2one ) Dog_ SCGN ( ortholog_one2one ) GuineaPig_ SCGN ( ortholog_one2one ) Macaque_ SCGN ( ortholog_one2one ) Mouse_ Scgn ( ortholog_one2one ) Pig_ SCGN ( ortholog_one2one ) Rat_ Scgn ( ortholog_one2one ) Rabbit_ SCGN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CALB1, CALB2 |
| Tissue | cerebellum, pituitary.gland, brain, pancreas, cerebellar.hemisphere, sigmoid.colon |
| Tissue Specificity | Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. {ECO:0000269|PubMed:11709487}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6942245 |
| Subcellular location [CC] | Cytoplasm. Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. {ECO:0000250}. |
| Mouse PG classification | NA |
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