| Gene Information | |
|---|---|
| Gene Name | CCND1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 295 |
| Protein Names | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) |
| Target Name | g1/s-specific cyclin-d1 |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000110092 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P24385 |
| Gene Card | CCND1 |
| Uniprot ID | P24385 |
| Pfam | PF02984; PF00134 |
| In ASD | no |
| Allosteric Prediction | yes (1.088871153) |
| Ortholog in Animals | Alpaca_ CCND1 ( ortholog_one2one ) Dog_ CCND1 ( ortholog_one2one ) GuineaPig_ CCND1 ( ortholog_one2one ) Macaque_ CCND1 ( ortholog_one2one ) Mouse_ Ccnd1 ( ortholog_one2one ) Pig_ CCND1 ( ortholog_one2one ) Rat_ Ccnd1 ( ortholog_one2one ) |
| Ohnologs | CCND2, CCND3 |
| Paralogs | CCNB1, CCNE2, CCNG1, CCNB3, CCNB2, CCNA1, CCNI, CCNP, CCNA2, CCNE1, CCNI2, CCNG2, CCNJL, CCND2, CCNJ, CCNO, CCND3, CCNF |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002190(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2W96 (X-ray 2.30A ) 2W99 (X-ray 2.80A ) 2W9F (X-ray 2.85A ) 2W9Z (X-ray 2.45A ) 5VZU (X-ray 2.70A ) 6P8E (X-ray 2.30A ) 6P8F (X-ray 2.89A ) 6P8G (X-ray 2.80A ) 6P8H (X-ray 3.19A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:9106657}. Cytoplasm {ECO:0000269|PubMed:9106657}. Nucleus membrane {ECO:0000269|PubMed:9106657}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000269|PubMed:9106657}. |
| Mouse PG classification | LPG |
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