| Gene Information | |
|---|---|
| Gene Name | APBB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 486 |
| Protein Names | Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000113108 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95704 |
| Gene Card | APBB3 |
| Uniprot ID | O95704 |
| Pfam | PF00640 |
| In ASD | no |
| Allosteric Prediction | no (-0.268527462) |
| Ortholog in Animals | Alpaca_ APBB3 ( ortholog_one2one ) Dog_ APBB3 ( ortholog_one2one ) GuineaPig_ APBB3 ( ortholog_one2one ) Macaque_ APBB3 ( ortholog_one2one ) Mouse_ Apbb3 ( ortholog_one2one ) Pig_ APBB3 ( ortholog_one2one ) Rat_ Apbb3 ( ortholog_one2one ) Rabbit_ APBB3 ( ortholog_one2one ) |
| Ohnologs | APBB2 |
| Paralogs | APBB2, APBB1 |
| Tissue | NA |
| Tissue Specificity | Expressed in various tissues, highest expression in brain. {ECO:0000269|PubMed:12153398}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DYQ (X-ray 3.10A ) 2YSC (NMR - ) |
| DBSNP | rs7715021 rs250430 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12153398}. Nucleus {ECO:0000269|PubMed:12153398}.; [Isoform I-214]: Nucleus.; [Isoform I-245]: Nucleus. |
| Mouse PG classification | NA |
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