| Gene Information | |
|---|---|
| Gene Name | SCC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1258 |
| Protein Names | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WVM7 |
| Gene Card | STAG1 |
| Uniprot ID | Q8WVM7 |
| Pfam | PF08514 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.132053(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 5QSM (X-ray 2.74A ) 5QSN (X-ray 2.66A ) 5QSO (X-ray 2.70A ) 5QSP (X-ray 2.89A ) 5QSQ (X-ray 2.48A ) 5QSR (X-ray 3.28A ) 5QSS (X-ray 3.08A ) 5QST (X-ray 2.58A ) 5QSU (X-ray 2.73A ) 5QSV (X-ray 2.76A ) 5QSW (X-ray 3.03A ) 5QSX (X-ray 2.34A ) 5QSY (X-ray 2.40A ) 5QSZ (X-ray 3.08A ) 6QB5 (X-ray 2.02A ) 6R7O (X-ray 2.31A ) 6RRC (X-ray 2.37A ) 6RRK (X-ray 3.17A ) 6WG3 (EM 5.30A ) |
| DBSNP | rs1559904167 rs1553738694 rs1553738686 rs1057519153 rs1553728634 rs1553727865 rs1376334317 rs1559824939 rs1553722309 rs1471479119 rs34149860 |
| Subcellular location [CC] | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. |
| Mouse PG classification | NA |
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