| Gene Information | |
|---|---|
| Gene Name | FCRLA |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000132185 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7L513 |
| Gene Card | FCRLA |
| Uniprot ID | Q7L513 |
| Pfam | PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-1.240396134) |
| Ortholog in Animals | Alpaca_ FCRLA ( ortholog_one2one ) Dog_ FCRLA ( ortholog_one2one ) GuineaPig_ FCRLA ( ortholog_one2one ) Macaque_ FCRLA ( ortholog_one2one ) Mouse_ Fcrla ( ortholog_one2one ) Pig_ FCRLA ( ortholog_one2one ) Rat_ Fcrla ( ortholog_one2one ) Rabbit_ FCRLA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PECAM1, FCRLB, C17orf99, FCRL6, FCGR3B, FCGR2A, FCGR2B, FCGR3A, FCGR1A, FCER1A, FCGR2C, FCRL5, FCRL4, MILR1, FCRL2, FCRL3, FCRL1 |
| Tissue | lymph.node, spleen, tonsil |
| Tissue Specificity | Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes. {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:12202404, ECO:0000269|PubMed:15551350}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4HWN (X-ray 2.01A ) |
| DBSNP | rs11746 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:15551350}. Note=Seems not to be secreted. {ECO:0000269|PubMed:11891275}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |