| Gene Information | |
|---|---|
| Gene Name | DAB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 770 |
| Protein Names | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000153071 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P98082 |
| Gene Card | DAB2 |
| Uniprot ID | P98082 |
| Pfam | PF00640 |
| In ASD | no |
| Allosteric Prediction | yes (0.68540438) |
| Ortholog in Animals | Alpaca_ DAB2 ( ortholog_one2one ) Dog_ DAB2 ( ortholog_one2one ) Macaque_ DAB2 ( ortholog_one2one ) Mouse_ Dab2 ( ortholog_one2one ) Pig_ DAB2 ( ortholog_one2one ) Rat_ Dab2 ( ortholog_one2one ) Rabbit_ DAB2 ( ortholog_one2one ) |
| Ohnologs | DAB1 |
| Paralogs | MAPK8IP2, C1orf226, NOS1AP, NUMBL, NUMB, LDLRAP1, MAPK8IP1, FAM43B, FAM43A, GULP1, DAB1 |
| Tissue | NA |
| Tissue Specificity | Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level). {ECO:0000269|PubMed:10340382, ECO:0000269|PubMed:15134832, ECO:0000269|PubMed:9620555}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001445(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LSW (NMR - ) 6O5O (X-ray 1.75A ) 6OVF (X-ray 1.95A ) |
| DBSNP | rs700241 rs3733801 |
| Subcellular location [CC] | Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm. |
| Mouse PG classification | NA |
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