| Gene Information | |
|---|---|
| Gene Name | AP3B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1082 |
| Protein Names | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000103723 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13367 |
| Gene Card | AP3B2 |
| Uniprot ID | Q13367 |
| Pfam | PF01602; PF14796 |
| In ASD | no |
| Allosteric Prediction | no (-0.850988909) |
| Ortholog in Animals | Alpaca_ AP3B2 ( ortholog_one2one ) Dog_ AP3B2 ( ortholog_one2one ) GuineaPig_ AP3B2 ( ortholog_one2one ) Macaque_ AP3B2 ( ortholog_one2one ) Mouse_ Ap3b2 ( ortholog_one2one ) Pig_ AP3B2 ( ortholog_one2one ) Rabbit_ AP3B2 ( ortholog_one2one ) |
| Ohnologs | AP3B1 |
| Paralogs | AP1B1, AP4B1, AP2B1, AP3B1 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum, pituitary.gland |
| Tissue Specificity | Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression) (PubMed:1851215). Isoform 2 is expressed at high levels in brain and testis (PubMed:17453999). {ECO:0000269|PubMed:17453999, ECO:0000269|PubMed:1851215}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047619(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
| Mouse PG classification | NA |
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