Gene Information
Gene NameCLASP2
OrganismHomo sapiens (Human)
Gene Length1294
Protein NamesCLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000163539 )
Evolutionary StageEukaryota
AlphaFoldDBO75122
Gene CardCLASP2
Uniprot IDO75122
PfamPF12348
In ASDno
Allosteric Predictionno (-0.089375093)
Ortholog in AnimalsAlpaca_ CLASP2 ( ortholog_one2one )
Dog_ CLASP2 ( ortholog_one2one )
GuineaPig_ CLASP2 ( ortholog_one2one )
Macaque_ CLASP2 ( ortholog_one2one )
Mouse_ Clasp2 ( ortholog_one2one )
Pig_ CLASP2 ( ortholog_one2one )
Rat_ Clasp2 ( ortholog_one2one )
Rabbit_ CLASP2 ( ortholog_one2one )
OhnologsCLASP1
ParalogsTOGARAM2, CLASP1, TOGARAM1
TissueNA
Tissue SpecificityBrain-specific.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3WOY  (X-ray  2.10A  )  5NR4  (X-ray  1.20A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:20937854}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16914514}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BRT1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17543864}. Cell membrane {ECO:0000269|PubMed:20937854}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20937854}. Note=Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. {ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:20937854}.
Mouse PG classificationNA
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