| Gene Information | |
|---|---|
| Gene Name | SCAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 389 |
| Protein Names | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000114650 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NP31 |
| Gene Card | SH2D2A |
| Uniprot ID | Q9NP31 |
| Pfam | PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.0327514) |
| Ortholog in Animals | Alpaca_ SCAP ( ortholog_one2one ) Dog_ SCAP ( ortholog_one2one ) GuineaPig_ SCAP ( ortholog_one2one ) Macaque_ SCAP ( ortholog_one2one ) Mouse_ Scap ( ortholog_one2one ) Pig_ SCAP ( ortholog_one2one ) Rat_ Scap ( ortholog_one2one ) Rabbit_ SCAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DISP1, DISP3, NPC1, PTCHD1, PTCH2, PTCHD3, PTCHD4, NPC1L1, DISP2, PTCH1 |
| Tissue | NA |
| Tissue Specificity | Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs926103 rs12072861 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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