| Gene Information | |
|---|---|
| Gene Name | SCAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1279 |
| Protein Names | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000114650 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q12770 |
| Gene Card | SCAP |
| Uniprot ID | Q12770 |
| Pfam | PF12349; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.0327514) |
| Ortholog in Animals | Alpaca_ SCAP ( ortholog_one2one ) Dog_ SCAP ( ortholog_one2one ) GuineaPig_ SCAP ( ortholog_one2one ) Macaque_ SCAP ( ortholog_one2one ) Mouse_ Scap ( ortholog_one2one ) Pig_ SCAP ( ortholog_one2one ) Rat_ Scap ( ortholog_one2one ) Rabbit_ SCAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DISP1, DISP3, NPC1, PTCHD1, PTCH2, PTCHD3, PTCHD4, NPC1L1, DISP2, PTCH1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.008990(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6M49 (EM 3.70A ) 7ETW (EM 4.10A ) |
| DBSNP | rs12487736 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:32111832}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:32111832}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:P97260}; Multi-pass membrane protein {ECO:0000255}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity). Requires the presence of SPRING1 for proper localization to endoplasmic reticulum (PubMed:32111832). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:32111832}. |
| Mouse PG classification | NA |
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