| Gene Information | |
|---|---|
| Gene Name | CCN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000104415 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95388 |
| Gene Card | CCN4 |
| Uniprot ID | O95388 |
| Pfam | PF00007; PF00219; PF19035; PF00093 |
| In ASD | no |
| Allosteric Prediction | no (-0.914240122) |
| Ortholog in Animals | Alpaca_ CCN4 ( ortholog_one2one ) Dog_ CCN4 ( ortholog_one2one ) GuineaPig_ CCN4 ( ortholog_one2one ) Macaque_ CCN4 ( ortholog_one2one ) Mouse_ Ccn4 ( ortholog_one2one ) Pig_ CCN4 ( ortholog_one2one ) Rat_ Ccn4 ( ortholog_one2one ) Rabbit_ CCN4 ( ortholog_one2one ) |
| Ohnologs | CCN5, CCN6, CCN2, CCN1 |
| Paralogs | CCN6, CCN3, CCN1, CCN2, CCN5 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35513885 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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