Gene Information
Gene NameSB1.8
OrganismHomo sapiens (Human)
Gene Length1233
Protein NamesStructural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ14683
Gene CardSMC1A
Uniprot IDQ14683
PfamPF06470; PF02463
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002267(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6WG3  (EM  5.30A  )  6WG4  (X-ray  2.31A  )  6WG6  (X-ray  3.54A  )  6WGE  (EM  3.90A  ) 
DBSNP rs34530151  rs2075725792  rs587784420  rs1556890815  rs727503773  rs587784403  rs122454122  rs2075701790  rs122454123  rs587784408  rs782176647  rs587784409  rs387906702  rs797045993  rs2075651835  rs587784416  rs587784418  rs1556885810 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
Mouse PG classificationNA
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