Gene Information
Gene NameSREBF2
OrganismHomo sapiens (Human)
Gene Length1141
Protein NamesSterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000198911 )
Evolutionary StageEumetazoa
AlphaFoldDBQ12772
Gene CardSREBF2
Uniprot IDQ12772
PfamPF00010
In ASDno
Allosteric Predictionyes (0.171391213)
Ortholog in AnimalsAlpaca_ SREBF2 ( ortholog_one2one )
Dog_ SREBF2 ( ortholog_one2one )
GuineaPig_ SREBF2 ( ortholog_one2one )
Macaque_ SREBF2 ( ortholog_one2one )
Mouse_ Srebf2 ( ortholog_one2one )
Pig_ SREBF2 ( ortholog_one2one )
Rat_ Srebf2 ( ortholog_one2one )
Rabbit_ SREBF2 ( ortholog_one2one )
OhnologsSREBF1
ParalogsUSF2, USF1, SREBF1
TissueNA
Tissue SpecificityUbiquitously expressed in adult and fetal tissues. {ECO:0000269|PubMed:7903453}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003212(Rat);0.044444(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1UKL  (X-ray  3.00A  ) 
DBSNP rs17002714  rs2228314  rs2229440  rs2228313 
Subcellular location [CC][Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038};
Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000303|PubMed:28849786};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000303|PubMed:28849786};
Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). {ECO:0000269|PubMed:32322062}.;
[Processed sterol regulatory element-binding protein 2]: Nucleus {ECO:0000269|PubMed:11477106, ECO:0000269|PubMed:32322062}. Note=Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. {ECO:0000250|UniProtKB:Q3U1N2}.
Mouse PG classificationNA
click here to return to the previous page