| Gene Information | |
|---|---|
| Gene Name | SAXO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Stabilizer of axonemal microtubules 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000155875 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IYX7 |
| Gene Card | SAXO1 |
| Uniprot ID | Q8IYX7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.286544615) |
| Ortholog in Animals | Alpaca_ SAXO1 ( ortholog_one2one ) Dog_ SAXO1 ( ortholog_one2one ) Macaque_ SAXO1 ( ortholog_one2one ) Mouse_ Saxo1 ( ortholog_one2one ) Pig_ SAXO1 ( ortholog_one2one ) Rat_ Saxo1 ( ortholog_one2one ) Rabbit_ SAXO1 ( ortholog_one2one ) |
| Ohnologs | SAXO2 |
| Paralogs | SAXO2 |
| Tissue | testis |
| Tissue Specificity | Widely expressed, with highest levels in testis. Expressed in mature spermatozoa (at protein level). {ECO:0000269|PubMed:25673876}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7021572 rs6475273 rs34119945 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25673876}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:25673876}. Note=In multi-ciliated cells, localizes to the basal bodies and in non-ciliated cells, to the centrosome. In spermatozoa, colocalizes with microtubules along the length of the axoneme from its proximal end to its distal tip and with tubulin at the distal end of the flagellum and at the proximal centriole. {ECO:0000269|PubMed:25673876}. |
| Mouse PG classification | NA |
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