| Gene Information | |
|---|---|
| Gene Name | LGI3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 548 |
| Protein Names | Leucine-rich repeat LGI family member 3 (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000168481 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N145 |
| Gene Card | LGI3 |
| Uniprot ID | Q8N145 |
| Pfam | PF03736; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-0.914950657) |
| Ortholog in Animals | Alpaca_ LGI3 ( ortholog_one2one ) Dog_ LGI3 ( ortholog_one2one ) GuineaPig_ LGI3 ( ortholog_one2one ) Macaque_ LGI3 ( ortholog_one2one ) Mouse_ Lgi3 ( ortholog_one2one ) Pig_ LGI3 ( ortholog_one2one ) Rat_ Lgi3 ( ortholog_one2one ) Rabbit_ LGI3 ( ortholog_one2one ) |
| Ohnologs | LGI1, LGI2 |
| Paralogs | LRG1, CPN2, LRRTM2, LRRC52, LRIT3, LRRC24, ELFN2, LRIG3, LGR6, LGR5, CHAD, CHADL, LRIT1, TRIL, ELFN1, LGR4, LGI2, LGI1, LRIG2, LRRC26, LRIG1, LGI4 |
| Tissue | brain, lung, cerebral.cortex, skin |
| Tissue Specificity | Widely expressed, with highest levels in brain and lung. {ECO:0000269|PubMed:12023020}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34112456 |
| Subcellular location [CC] | Secreted {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Found in the synaptosomal membrane fraction. {ECO:0000250}. |
| Mouse PG classification | NA |
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