| Gene Information | |
|---|---|
| Gene Name | SAV1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 383 |
| Protein Names | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000151748 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H4B6 |
| Gene Card | SAV1 |
| Uniprot ID | Q9H4B6 |
| Pfam | PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.473626991) |
| Ortholog in Animals | Alpaca_ SAV1 ( ortholog_one2one ) Dog_ SAV1 ( ortholog_one2one ) GuineaPig_ SAV1 ( ortholog_one2one ) Macaque_ SAV1 ( ortholog_one2one ) Mouse_ Sav1 ( ortholog_one2one ) Pig_ SAV1 ( ortholog_one2one ) Rat_ Sav1 ( ortholog_one2one ) Rabbit_ SAV1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAGI3, MAGI2, GRIP1, MAGIX, GRIP2, MAGI1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. {ECO:0000269|PubMed:19212654}. |
| Pharmacological Animal Models | 0.019824(Chimpanzee);0.039539(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6AO5 (X-ray 2.96A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654}. |
| Mouse PG classification | NA |
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