| Gene Information | |
|---|---|
| Gene Name | SATB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182568 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q01826 |
| Gene Card | SATB1 |
| Uniprot ID | Q01826 |
| Pfam | PF02376; PF16557; PF00046; PF16534 |
| In ASD | no |
| Allosteric Prediction | no (-0.068752598) |
| Ortholog in Animals | Alpaca_ SATB1 ( ortholog_one2one ) Dog_ SATB1 ( ortholog_one2one ) GuineaPig_ SATB1 ( ortholog_one2one ) Macaque_ SATB1 ( ortholog_one2one ) Mouse_ Satb1 ( ortholog_one2one ) Pig_ SATB1 ( ortholog_one2one ) Rat_ Satb1 ( ortholog_one2one ) Rabbit_ SATB1 ( ortholog_one2one ) |
| Ohnologs | SATB2 |
| Paralogs | SATB2 |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in thymus. {ECO:0000269|PubMed:1505028}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YSE (NMR - ) 2L1P (NMR - ) 2MW8 (NMR - ) 2O49 (X-ray 2.00A ) 2O4A (X-ray 1.75A ) 3NZL (X-ray 1.20A ) 3TUO (X-ray 1.70A ) 6LFF (X-ray 1.79A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus matrix {ECO:0000269|PubMed:10800076, ECO:0000269|PubMed:18408014}. Nucleus, PML body {ECO:0000269|PubMed:18408014}. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences (PubMed:12692553). When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:18408014). {ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:18408014}. |
| Mouse PG classification | NA |
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