| Gene Information | |
|---|---|
| Gene Name | AWAT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 333 |
| Protein Names | Acyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000147160 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6E213 |
| Gene Card | AWAT2 |
| Uniprot ID | Q6E213 |
| Pfam | PF03982 |
| In ASD | no |
| Allosteric Prediction | no (-1.083424806) |
| Ortholog in Animals | Alpaca_ AWAT2 ( ortholog_one2one ) Dog_ AWAT2 ( ortholog_one2one ) GuineaPig_ AWAT2 ( ortholog_one2one ) Macaque_ AWAT2 ( ortholog_one2one ) Mouse_ Awat2 ( ortholog_one2one ) Pig_ AWAT2 ( ortholog_one2one ) Rat_ Awat2 ( ortholog_one2one ) Rabbit_ AWAT2 ( ortholog_one2one ) |
| Ohnologs | DGAT2, MOGAT2 |
| Paralogs | DGAT2L6, AWAT1, DGAT2, MOGAT3, MOGAT2, MOGAT1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E1M8}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |