| Gene Information | |
|---|---|
| Gene Name | RECQL5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 991 |
| Protein Names | ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000108469 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O94762 |
| Gene Card | RECQL5 |
| Uniprot ID | O94762 |
| Pfam | PF00270; PF00271; PF06959; PF16124 |
| In ASD | no |
| Allosteric Prediction | no (-0.740761775) |
| Ortholog in Animals | Alpaca_ RECQL5 ( ortholog_one2one ) Dog_ RECQL5 ( ortholog_one2one ) GuineaPig_ RECQL5 ( ortholog_one2one ) Macaque_ RECQL5 ( ortholog_one2one ) Mouse_ Recql5 ( ortholog_one2one ) Pig_ RECQL5 ( ortholog_one2one ) Rat_ Recql5 ( ortholog_one2one ) Rabbit_ RECQL5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WRN, RECQL4, BLM, RECQL |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001375(Rat);0.032(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BK0 (X-ray 1.90A ) 5LB3 (X-ray 1.80A ) 5LB5 (X-ray 2.00A ) 5LB8 (X-ray 3.40A ) 5LBA (X-ray 2.50A ) 7ZML (X-ray 2.79A ) 7ZMM (X-ray 2.50A ) 7ZMN (X-ray 3.20A ) 7ZMO (X-ray 3.75A ) 7ZMP (X-ray 3.63A ) 7ZMQ (X-ray 2.70A ) 7ZMR (X-ray 3.30A ) 7ZMS (X-ray 2.70A ) 7ZMT (X-ray 2.50A ) 7ZMV (X-ray 2.00A ) |
| DBSNP | rs820196 rs35566780 |
| Subcellular location [CC] | [Isoform Beta]: Nucleus, nucleoplasm {ECO:0000269|PubMed:10710432, ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:23715498}. Nucleus {ECO:0000269|PubMed:23180761}. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re-localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase (PubMed:23180761). {ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:23715498}.; [Isoform Alpha]: Cytoplasm {ECO:0000269|PubMed:10710432}.; [Isoform Gamma]: Cytoplasm {ECO:0000269|PubMed:10710432}. |
| Mouse PG classification | NA |
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