| Gene Information | |
|---|---|
| Gene Name | SARM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 724 |
| Protein Names | NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000004139 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6SZW1 |
| Gene Card | SARM1 |
| Uniprot ID | Q6SZW1 |
| Pfam | PF07647; PF13676 |
| In ASD | yes |
| Allosteric Prediction | no (-0.368749529) |
| Ortholog in Animals | Alpaca_ SARM1 ( ortholog_one2one ) Dog_ SARM1 ( ortholog_one2one ) GuineaPig_ SARM1 ( ortholog_one2one ) Macaque_ SARM1 ( ortholog_one2one ) Mouse_ Sarm1 ( ortholog_one2one ) Rat_ Sarm1 ( ortholog_one2one ) Rabbit_ SARM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta. {ECO:0000269|PubMed:11386760, ECO:0000269|PubMed:17724133}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6O0Q (X-ray 1.80A ) 6O0R (X-ray 1.80A ) 6O0S (X-ray 2.70A ) 6O0T (X-ray 2.80A ) 6O0U (X-ray 3.03A ) 6O0V (X-ray 2.07A ) 6O1B (X-ray 1.67A ) 6QWV (X-ray 2.47A ) 6WPK (EM 3.30A ) 6ZFX (EM 2.88A ) 6ZG0 (EM 7.70A ) 6ZG1 (EM 3.77A ) 7ANW (EM 2.68A ) 7CM5 (EM 2.60A ) 7CM6 (EM 3.00A ) 7CM7 (EM 2.60A ) 7DJT (EM 2.80A ) 7KNQ (EM 3.40A ) 7LD0 (EM 3.10A ) 7NAG (X-ray 1.72A ) 7NAH (X-ray 1.79A ) 7NAI (X-ray 1.74A ) 7NAJ (X-ray 1.60A ) 7NAK (EM 2.90A ) 7NAL (EM 3.00A ) |
| DBSNP | rs7212814 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20306472}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PDS3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6PDS3}. Synapse {ECO:0000250|UniProtKB:Q6PDS3}. Mitochondrion {ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:22145856}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q6PDS3}. |
| Mouse PG classification | NA |
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