| Gene Information | |
|---|---|
| Gene Name | SAPK1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P53779 |
| Gene Card | MAPK10 |
| Uniprot ID | P53779 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JNK (X-ray 2.30A ) 1PMN (X-ray 2.20A ) 1PMU (X-ray 2.70A ) 1PMV (X-ray 2.50A ) 2B1P (X-ray 1.90A ) 2EXC (X-ray 2.75A ) 2O0U (X-ray 2.10A ) 2O2U (X-ray 2.45A ) 2OK1 (X-ray 2.40A ) 2P33 (X-ray 2.40A ) 2R9S (X-ray 2.40A ) 2WAJ (X-ray 2.40A ) 2ZDT (X-ray 2.00A ) 2ZDU (X-ray 2.50A ) 3CGF (X-ray 3.00A ) 3CGO (X-ray 3.00A ) 3DA6 (X-ray 2.00A ) 3FI2 (X-ray 2.28A ) 3FI3 (X-ray 2.20A ) 3FV8 (X-ray 2.28A ) 3G90 (X-ray 2.40A ) 3G9L (X-ray 2.20A ) 3G9N (X-ray 2.80A ) 3KVX (X-ray 2.40A ) 3OXI (X-ray 2.20A ) 3OY1 (X-ray 1.70A ) 3PTG (X-ray 2.43A ) 3RTP (X-ray 2.40A ) 3TTI (X-ray 2.20A ) 3TTJ (X-ray 2.10A ) 3V6R (X-ray 2.60A ) 3V6S (X-ray 2.97A ) 4H36 (X-ray 3.00A ) 4H39 (X-ray 1.99A ) 4H3B (X-ray 2.08A ) 4KKE (X-ray 2.20A ) 4KKG (X-ray 2.40A ) 4KKH (X-ray 2.00A ) 4U79 (X-ray 2.23A ) 4W4V (X-ray 2.01A ) 4W4W (X-ray 1.90A ) 4W4X (X-ray 2.65A ) 4W4Y (X-ray 2.30A ) 4WHZ (X-ray 1.79A ) 4X21 (X-ray 1.95A ) 4Y46 (X-ray 2.04A ) 4Y5H (X-ray 2.06A ) 4Z9L (X-ray 2.10A ) 6EKD (X-ray 2.10A ) 6EMH (X-ray 1.76A ) 6EQ9 (X-ray 1.83A ) 7KSI (X-ray 1.73A ) 7KSJ (X-ray 2.06A ) 7KSK (X-ray 1.84A ) 7ORE (X-ray 2.18A ) 7ORF (X-ray 1.70A ) 7S1N (X-ray 2.11A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16737965}. Membrane {ECO:0000269|PubMed:16737965}; Lipid-anchor {ECO:0000269|PubMed:16737965}. Nucleus {ECO:0000269|PubMed:16737965}. Mitochondrion {ECO:0000269|PubMed:16737965}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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