| Gene Information | |
|---|---|
| Gene Name | SAPCD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000186193 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86UD0 |
| Gene Card | SAPCD2 |
| Uniprot ID | Q86UD0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.674941333) |
| Ortholog in Animals | Alpaca_ SAPCD2 ( ortholog_one2one ) Dog_ SAPCD2 ( ortholog_one2one ) GuineaPig_ SAPCD2 ( ortholog_one2one ) Macaque_ SAPCD2 ( ortholog_one2one ) Mouse_ Sapcd2 ( ortholog_one2one ) Pig_ SAPCD2 ( ortholog_one2one ) Rat_ Sapcd2 ( ortholog_one2one ) Rabbit_ SAPCD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SAPCD1 |
| Tissue | brain |
| Tissue Specificity | Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824). {ECO:0000269|PubMed:17525738, ECO:0000269|PubMed:23704824}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17525738}. Nucleus {ECO:0000269|PubMed:17525738}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26766442}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction {ECO:0000269|PubMed:26766442}. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis. {ECO:0000250|UniProtKB:Q9D818}. |
| Mouse PG classification | NA |
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