| Gene Information | |
|---|---|
| Gene Name | RECQL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1208 |
| Protein Names | ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000160957 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O94761 |
| Gene Card | RECQL4 |
| Uniprot ID | O94761 |
| Pfam | PF00270; PF11719; PF00271 |
| In ASD | no |
| Allosteric Prediction | no (-0.71506483) |
| Ortholog in Animals | Alpaca_ RECQL4 ( ortholog_one2one ) Dog_ RECQL4 ( ortholog_one2one ) GuineaPig_ RECQL4 ( ortholog_one2one ) Mouse_ Recql4 ( ortholog_one2one ) Pig_ RECQL4 ( ortholog_one2one ) Rat_ Recql4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WRN, RECQL5, BLM, RECQL |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in thymus and testis. {ECO:0000269|PubMed:9878247}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001668(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KMU (NMR - ) 5LST (X-ray 2.75A ) |
| DBSNP | rs35198096 rs34642881 rs2721190 rs199543866 rs34371341 rs4244612 rs34103564 rs34633809 rs374743591 rs557142414 rs35407712 rs35842750 rs754735053 rs2721191 rs786200890 rs137853229 rs1034558903 rs35098923 rs34293591 rs33972310 rs35070885 rs36023964 rs4251691 rs34666647 rs137853232 rs4925828 rs35348691 rs36078464 rs34915097 rs34236392 rs35101495 rs35346077 rs772265082 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15317757}. Nucleus {ECO:0000269|PubMed:10552928}. |
| Mouse PG classification | NA |
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