Gene Information
Gene NameATP13A2
OrganismHomo sapiens (Human)
Gene Length1180
Protein NamesPolyamine-transporting ATPase 13A2 (EC 7.6.2.-)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000159363 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NQ11
Gene CardATP13A2
Uniprot IDQ9NQ11
PfamPF12409
In ASDno
Allosteric Predictionno (-0.151711012)
Ortholog in AnimalsAlpaca_ ATP13A2 ( ortholog_one2one )
Dog_ ATP13A2 ( ortholog_one2one )
GuineaPig_ ATP13A2 ( ortholog_one2one )
Macaque_ ATP13A2 ( ortholog_one2one )
Mouse_ Atp13a2 ( ortholog_one2one )
Pig_ ATP13A2 ( ortholog_one2one )
Rat_ Atp13a2 ( ortholog_one2one )
Rabbit_ ATP13A2 ( ortholog_one2one )
OhnologsATP13A4, ATP13A3, ATP13A5
ParalogsATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1
TissueNA
Tissue SpecificityExpressed in brain;
protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level). {ECO:0000269|PubMed:22186024}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7M5V  (EM  2.90A  )  7M5X  (EM  2.70A  )  7M5Y  (EM  3.00A  )  7N70  (EM  2.80A  )  7N72  (EM  2.50A  )  7N73  (EM  2.90A  )  7N74  (EM  2.80A  )  7N75  (EM  2.90A  )  7N76  (EM  2.90A  )  7N77  (EM  3.20A  )  7N78  (EM  3.00A  )  7VPI  (EM  3.50A  )  7VPJ  (EM  3.50A  )  7VPK  (EM  3.50A  )  7VPL  (EM  3.50A  ) 
DBSNP rs151117874  rs56379718  rs56367069  rs56275621  rs772446950  rs121918227  rs1057519291  rs56186751  rs147277743  rs55635527  rs56170027  rs587777053  rs144701072  rs55708915  rs137853967  rs774238872 
Subcellular location [CC]Lysosome membrane {ECO:0000269|PubMed:21542062, ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22768177, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:28137957};
Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396};
Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:24603074};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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