| Gene Information | |
|---|---|
| Gene Name | PP10436 |
| Organism | Homo sapiens (Human) |
| Gene Length | 777 |
| Protein Names | Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9HBF4 |
| Gene Card | ZFYVE1 |
| Uniprot ID | Q9HBF4 |
| Pfam | PF01363 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: Highly expressed in heart. Also detected in the testis. {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:11256955}.; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart. {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:11256955}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, Golgi stack {ECO:0000269|PubMed:11256955}. Golgi apparatus {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:25876663}. Endoplasmic reticulum {ECO:0000269|PubMed:11024279, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25876663, ECO:0000269|PubMed:30970241}. Lipid droplet {ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}. Preautophagosomal structure {ECO:0000269|PubMed:25876663, ECO:0000269|PubMed:31293035, ECO:0000269|PubMed:33499712}. Mitochondrion {ECO:0000269|PubMed:25876663}. Note=Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). {ECO:0000269|PubMed:11256955, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035}. |
| Mouse PG classification | NA |
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