| Gene Information | |
|---|---|
| Gene Name | ARG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 354 |
| Protein Names | Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase) |
| Target Name | arginase-2, mitochondrial |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000081181 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P78540 |
| Gene Card | ARG2 |
| Uniprot ID | P78540 |
| Pfam | PF00491 |
| In ASD | yes |
| Allosteric Prediction | yes (0.526136363) |
| Ortholog in Animals | Alpaca_ ARG2 ( ortholog_one2one ) Dog_ ARG2 ( ortholog_one2one ) GuineaPig_ ARG2 ( ortholog_one2one ) Macaque_ ARG2 ( ortholog_one2one ) Mouse_ Arg2 ( ortholog_one2one ) Pig_ ARG2 ( ortholog_one2one ) Rat_ Arg2 ( ortholog_one2one ) Rabbit_ ARG2 ( ortholog_one2one ) |
| Ohnologs | ARG1 |
| Paralogs | ARG1, AGMAT |
| Tissue | NA |
| Tissue Specificity | Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. Expressed in activated T cells (PubMed:27745970). {ECO:0000269|PubMed:27745970}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1PQ3 (X-ray 2.70A ) 4HZE (X-ray 1.60A ) 4I06 (X-ray 1.80A ) 4IE2 (X-ray 2.21A ) 4IE3 (X-ray 2.35A ) 4IXU (X-ray 1.90A ) 4IXV (X-ray 2.30A ) 6Q37 (X-ray 2.21A ) 6Q39 (X-ray 2.21A ) 6SS2 (X-ray 2.40A ) 6SS4 (X-ray 2.90A ) 6SS6 (X-ray 3.25A ) |
| DBSNP | rs17104534 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:8898077}. |
| Mouse PG classification | NA |
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