| Gene Information | |
|---|---|
| Gene Name | AGRP |
| Organism | Homo sapiens (Human) |
| Gene Length | 132 |
| Protein Names | Agouti-related protein |
| Target Name | agouti-related protein |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000159723 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00253 |
| Gene Card | AGRP |
| Uniprot ID | O00253 |
| Pfam | PF05039 |
| In ASD | no |
| Allosteric Prediction | no (-0.581114854) |
| Ortholog in Animals | Alpaca_ AGRP ( ortholog_one2one ) Dog_ AGRP ( ortholog_one2one ) GuineaPig_ AGRP ( ortholog_one2one ) Macaque_ AGRP ( ortholog_one2one ) Mouse_ Agrp ( ortholog_one2one ) Pig_ AGRP ( ortholog_one2one ) Rat_ Agrp ( ortholog_one2one ) Rabbit_ AGRP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASIP |
| Tissue | epididymis, adrenal.gland, lung |
| Tissue Specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HYK (NMR - ) 1MR0 (NMR - ) |
| DBSNP | rs5030980 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}. |
| Mouse PG classification | HPG |
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