| Gene Information | |
|---|---|
| Gene Name | RNASE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 161 |
| Protein Names | Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US) |
| Target Name | non-secretory ribonuclease |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000169385 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10153 |
| Gene Card | RNASE2 |
| Uniprot ID | P10153 |
| Pfam | PF00074 |
| In ASD | no |
| Allosteric Prediction | no (-0.103940117) |
| Ortholog in Animals | Alpaca_ RNASE2 ( ortholog_one2one ) Mouse_ Ear1 ( ortholog_many2many ) Mouse_ Ear14 ( ortholog_many2many ) Mouse_ Ear10 ( ortholog_many2many ) Mouse_ Ear2 ( ortholog_many2many ) Mouse_ Rnase2a ( ortholog_many2many ) Mouse_ Rnase2b ( ortholog_many2many ) Mouse_ Ear6 ( ortholog_many2many ) Rat_ Ear1 ( ortholog_many2many ) Rat_ Rnase3 ( ortholog_many2many ) Rat_ Rnase17 ( ortholog_many2many ) Rat_ Rnase2 ( ortholog_many2many ) Rabbit_ RAF2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | RNASE3, RNASE10, RNASE9, RNASE6, RNASE1, RNASE11, ANG, RNASE4, RNASE12, RNASE13, RNASE8, RNASE7 |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | Liver, lung, spleen, leukocytes and body fluids. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GQV (X-ray 0.98A ) 1HI2 (X-ray 1.60A ) 1HI3 (X-ray 1.80A ) 1HI4 (X-ray 1.80A ) 1HI5 (X-ray 1.80A ) 1K2A (X-ray 1.00A ) 2BEX (X-ray 1.99A ) 2BZZ (X-ray 0.98A ) 2C01 (X-ray 1.24A ) 2C02 (X-ray 2.00A ) 2C05 (X-ray 1.86A ) 5E13 (X-ray 1.34A ) 6SSO (X-ray 1.21A ) |
| DBSNP | rs8012891 rs146887874 |
| Subcellular location [CC] | Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule. |
| Mouse PG classification | NA |
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