| Gene Information | |
|---|---|
| Gene Name | WASL |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106299 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00401 |
| Gene Card | WASL |
| Uniprot ID | O00401 |
| Pfam | PF00786; PF00568; PF02205 |
| In ASD | yes |
| Allosteric Prediction | yes (0.722124512) |
| Ortholog in Animals | Alpaca_ WASL ( ortholog_one2one ) Dog_ WASL ( ortholog_one2one ) GuineaPig_ WASL ( ortholog_one2one ) Macaque_ WASL ( ortholog_one2one ) Mouse_ Wasl ( ortholog_one2one ) Pig_ WASL ( ortholog_one2one ) Rat_ Wasl ( ortholog_one2one ) Rabbit_ WASL ( ortholog_one2one ) |
| Ohnologs | WAS |
| Paralogs | WAS |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001725(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FF3 (X-ray 2.00A ) 2LNH (NMR - ) 2VCP (X-ray 3.20A ) 4CC2 (X-ray 1.55A ) 4CC7 (X-ray 1.97A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9422512}. Nucleus {ECO:0000269|PubMed:16767080}. Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q91YD9}. |
| Mouse PG classification | NA |
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