| Gene Information | |
|---|---|
| Gene Name | SAG |
| Organism | Homo sapiens (Human) |
| Gene Length | 405 |
| Protein Names | S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000130561 ) 3 ( ENSG00000281857 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P10523 |
| Gene Card | SAG |
| Uniprot ID | P10523 |
| Pfam | PF02752; PF00339 |
| In ASD | no |
| Allosteric Prediction | yes (0.84524445) |
| Ortholog in Animals | Alpaca_ SAG ( ortholog_one2one ) Dog_ SAG ( ortholog_one2one ) GuineaPig_ SAG ( ortholog_one2one ) Macaque_ SAG ( ortholog_one2one ) Mouse_ Sag ( ortholog_one2one ) Pig_ SAG ( ortholog_one2one ) Rat_ Sag ( ortholog_one2one ) Rabbit_ SAG ( ortholog_one2one ) |
| Ohnologs | ARR3 |
| Paralogs | ARR3, ARRB1, ARRB2 |
| Tissue | NA |
| Tissue Specificity | Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level). {ECO:0000269|PubMed:3720866}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002808(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7565275 rs115857633 rs137886124 rs112613526 rs200602069 rs1427707173 rs1046976 rs1046974 |
| Subcellular location [CC] | Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:3720866}. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866). {ECO:0000250|UniProtKB:P08168, ECO:0000269|PubMed:3720866}. |
| Mouse PG classification | HPG |
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