Gene Information
Gene NameSACM1L
OrganismHomo sapiens (Human)
Gene Length587
Protein NamesPhosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000211456 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NTJ5
Gene CardSACM1L
Uniprot IDQ9NTJ5
PfamPF02383
In ASDno
Allosteric Predictionno (-0.758692175)
Ortholog in AnimalsAlpaca_ SACM1L ( ortholog_one2one )
Dog_ SACM1L ( ortholog_one2one )
GuineaPig_ SACM1L ( ortholog_one2one )
Macaque_ SACM1L ( ortholog_one2one )
Mouse_ Sacm1l ( ortholog_one2one )
Pig_ SACM1L ( ortholog_one2one )
Rat_ Sacm1l ( ortholog_one2one )
Rabbit_ SACM1L ( ortholog_one2one )
OhnologsNA
ParalogsSH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, OCRL, INPP5D, INPPL1, INPP5F, INPP5J, SYNJ1, INPP5B, INPP5K
TissueNA
Tissue SpecificityDetected in heart, brain, lung, liver, kidney, pancreas and testis. {ECO:0000269|PubMed:10048485}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1468542 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:31806350};
Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:31806350}. Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A (PubMed:31806350). Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate (PubMed:27044890). {ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:31806350}.
Mouse PG classificationNA
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