| Gene Information | |
|---|---|
| Gene Name | ITGA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1179 |
| Protein Names | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) |
| Target Name | integrin alpha-1 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000213949 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P56199 |
| Gene Card | ITGA1 |
| Uniprot ID | P56199 |
| Pfam | PF01839; PF08441; PF00092 |
| In ASD | no |
| Allosteric Prediction | yes (0.486448614) |
| Ortholog in Animals | Alpaca_ ITGA1 ( ortholog_one2one ) Dog_ ITGA1 ( ortholog_one2one ) GuineaPig_ ITGA1 ( ortholog_one2one ) Macaque_ ITGA1 ( ortholog_one2one ) Mouse_ Itga1 ( ortholog_one2one ) Pig_ ITGA1 ( ortholog_one2one ) Rat_ Itga1 ( ortholog_one2one ) Rabbit_ ITGA1 ( ortholog_one2one ) |
| Ohnologs | ITGAL, ITGA11, ITGA10 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PT6 (X-ray 1.87A ) 1QC5 (X-ray 2.00A ) 1QCY (X-ray 2.30A ) 2L8S (NMR - ) 2M32 (NMR - ) 4A0Q (X-ray 1.90A ) 5HGJ (X-ray 1.40A ) |
| DBSNP | rs4145748 rs2279587 rs12520591 rs988574 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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