| Gene Information | |
|---|---|
| Gene Name | MTHFD1L |
| Organism | Homo sapiens (Human) |
| Gene Length | 978 |
| Protein Names | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120254 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q6UB35 |
| Gene Card | MTHFD1L |
| Uniprot ID | Q6UB35 |
| Pfam | PF01268; PF00763; PF02882 |
| In ASD | no |
| Allosteric Prediction | no (-0.787782813) |
| Ortholog in Animals | Alpaca_ MTHFD1L ( ortholog_one2one ) Dog_ MTHFD1L ( ortholog_one2one ) GuineaPig_ MTHFD1L ( ortholog_one2one ) Macaque_ MTHFD1L ( ortholog_one2one ) Mouse_ Mthfd1l ( ortholog_one2one ) Pig_ MTHFD1L ( ortholog_one2one ) Rat_ Mthfd1l ( ortholog_one2one ) Rabbit_ MTHFD1L ( ortholog_one2one ) |
| Ohnologs | MTHFD1 |
| Paralogs | MTHFD2L, MTHFD1, MTHFD2 |
| Tissue | NA |
| Tissue Specificity | Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. {ECO:0000269|PubMed:12937168, ECO:0000269|PubMed:15013446}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:12937168}. |
| Mouse PG classification | NA |
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