| Gene Information | |
|---|---|
| Gene Name | YWHAQ |
| Organism | Homo sapiens (Human) |
| Gene Length | 245 |
| Protein Names | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) |
| Target Name | 14-3-3 protein theta |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134308 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P27348 |
| Gene Card | YWHAQ |
| Uniprot ID | P27348 |
| Pfam | PF00244 |
| In ASD | no |
| Allosteric Prediction | yes (1.099379142) |
| Ortholog in Animals | Alpaca_ YWHAQ ( ortholog_one2one ) Dog_ YWHAQ ( ortholog_one2many ) Mouse_ Ywhaq ( ortholog_one2one ) Pig_ YWHAQ ( ortholog_one2one ) Rat_ AC141966.1 ( ortholog_one2one ) Rabbit_ YWHAQ ( ortholog_one2one ) |
| Ohnologs | YWHAZ, YWHAB, SFN |
| Paralogs | YWHAZ, YWHAE, YWHAB, SFN, YWHAH, YWHAG |
| Tissue | substantia.nigra |
| Tissue Specificity | Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269|PubMed:11080204}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.002353(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2BTP (X-ray 2.80A ) 5IQP (X-ray 2.60A ) 6BCR (X-ray 1.99A ) 6BD2 (X-ray 2.90A ) 6BQT (X-ray 2.80A ) 6KZG (X-ray 2.00A ) 6KZH (X-ray 2.65A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Note=In neurons, axonally transported to the nerve terminals. |
| Mouse PG classification | NA |
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