| Gene Information | |
|---|---|
| Gene Name | PLA2G1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 148 |
| Protein Names | Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) |
| Target Name | phospholipase a2 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000170890 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P04054 |
| Gene Card | PLA2G1B |
| Uniprot ID | P04054 |
| Pfam | PF00068 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999680212) |
| Ortholog in Animals | Alpaca_ PLA2G1B ( ortholog_one2one ) Dog_ PLA2G1B ( ortholog_one2one ) GuineaPig_ PLA2G1B ( ortholog_one2one ) Macaque_ PLA2G1B ( ortholog_one2one ) Mouse_ Pla2g1b ( ortholog_one2one ) Pig_ PLA2G1B ( ortholog_one2one ) Rat_ Pla2g1b ( ortholog_one2one ) Rabbit_ PLA2G1B ( ortholog_one2one ) |
| Ohnologs | PLA2G10 |
| Paralogs | PLA2G2D, PLA2G2C, PLA2G2F, PLA2G10, PLA2G2A, PLA2G5, PLA2G2E, OC90 |
| Tissue | pancreas |
| Tissue Specificity | Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis. {ECO:0000269|PubMed:10681567}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3ELO (X-ray 1.55A ) 6Q42 (X-ray 1.90A ) |
| DBSNP | rs5632 rs5636 rs5635 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:19297324}. Note=Secreted from pancreatic acinar cells in its inactive form. |
| Mouse PG classification | NA |
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