| Gene Information | |
|---|---|
| Gene Name | ZFYVE26 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2539 |
| Protein Names | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000072121 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q68DK2 |
| Gene Card | ZFYVE26 |
| Uniprot ID | Q68DK2 |
| Pfam | PF01363 |
| In ASD | no |
| Allosteric Prediction | no (-1.18860842) |
| Ortholog in Animals | Alpaca_ ZFYVE26 ( ortholog_one2one ) Dog_ ZFYVE26 ( ortholog_one2one ) GuineaPig_ ZFYVE26 ( ortholog_one2one ) Macaque_ ZFYVE26 ( ortholog_one2one ) Mouse_ Zfyve26 ( ortholog_one2one ) Pig_ ZFYVE26 ( ortholog_one2one ) Rat_ Zfyve26 ( ortholog_one2one ) Rabbit_ ZFYVE26 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RUFY1, PLEKHF1, ZFYVE1, ZFYVE28, RUNDC3B, RUFY2, PLEKHM2, RUFY3, RUNDC3A, ZFYVE16, PLEKHF2, SNX29, ZFYVE19 |
| Tissue | NA |
| Tissue Specificity | Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. {ECO:0000269|PubMed:18394578}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34059852 rs17192170 rs35471427 rs7156206 rs3742885 rs3742884 rs2235967 rs3742883 rs200595749 rs34373049 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20208530}. Midbody {ECO:0000269|PubMed:20208530}. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A. |
| Mouse PG classification | HPG |
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