| Gene Information | |
|---|---|
| Gene Name | RYR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4870 |
| Protein Names | Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000198838 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | RYR3 |
| Uniprot ID | Q15413 |
| Pfam | PF08709; PF00520; PF02815; PF08454; PF06459; PF01365; PF02026; PF00622 |
| In ASD | yes |
| Allosteric Prediction | yes (1.191519003) |
| Ortholog in Animals | Alpaca_ RYR3 ( ortholog_one2one ) Dog_ RYR3 ( ortholog_one2one ) GuineaPig_ RYR3 ( ortholog_one2one ) Macaque_ RYR3 ( ortholog_one2one ) Mouse_ Ryr3 ( ortholog_one2one ) Pig_ RYR3 ( ortholog_one2one ) Rabbit_ RYR3 ( ortholog_one2one ) |
| Ohnologs | RYR1, RYR2 |
| Paralogs | RYR2, ITPR2, ITPR3, RYR1, ITPR1 |
| Tissue | NA |
| Tissue Specificity | Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus. {ECO:0000269|PubMed:9395096, ECO:0000269|PubMed:9607712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4ERV (X-ray 1.75A ) 6UHA (X-ray 2.85A ) 6UHB (X-ray 2.50A ) 6UHE (X-ray 2.89A ) 6UHH (X-ray 3.14A ) |
| DBSNP | rs2304380 rs2077268 rs2229116 |
| Subcellular location [CC] | Sarcoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q9TS33}. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}. |
| Mouse PG classification | NA |
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